Murray, who was celebrating senior night with his teammates, helped the Bulldogs build a 28-10 lead over Kentucky Saturday night before he was injured.
"He went to the hospital to get an MRI," coach Mark Richt said after the game. "We'll just wait and see. He hurt it on the long run and it was bothering him."
Richt called Murray's injury "sickening." Also saying: "I had a hard time enjoying the rest of the game."
Richt went on to say that it was doubtful that Murray would return in a week's time to play rival Georgia Tech in Atlanta.
Murray left in a Georgia State Patrol car just after halftime of the contest - entering the front seat. Murray's mother and girlfriend were with him as was former Georgia Chaplin Kevin "Chappy" Hynes as he entered the vehicle.
Murray appeared to injure his knee during a scramble earlier in the quarter, but he stayed in the game after taking a turn on the stationary bicycle on the sideline.
He was hurt on a play that resulted in an interception.
Murray's left the contest as the all-time SEC records leader in the following categories: Completions (921), Passing Yards (13,166), TD Passes (121) and Total Offense (13,562). Murray tied David Greene with the most starts for a non-kicker in school history with 52 Saturday night, which is the most for any active NCAA player (school record is 53 by Blair Walsh).
The Bulldogs ended the game with a 59-17 win over the Wildcats. Backup QB Hutson Mason took over for Murray and ended his night 13 for 19 for 189 yards and a touchdown.